Fig. 1. TASK-1 channel blockade by A293. (a) Chemical structure of the aromatic carbonamide A293. (b-c) Human TASK-1 channels were heterologously expressed in Xenopus laevis oocytes. Families of TASK-1 current traces under control conditions (b) and after administration of 10 µM A293 (c). The voltage protocol is depicted as inset. (d) Time course of TASK-1 blockade by 240 nM or 10 µM of A293 (n = 3). Data are displayed as mean ± S.E.M.